Septicemic melioidosis is often a fatal disease despite treatment with antibiotics such as ceftazidime to which Burkholderia pseudomallei is sensitive in vitro. We report a case of B. pseudomallei causing sepsis in a diabetic patient. A 62 year old diabetic farmer, referred from a peripheral hospital with high grade fever and altered sensorium. Blood culture revealed B. pseudomallei. The patient was treated with meropenemand responded well to the treatment.