Oral infection, particularly periodontitis, has recently been recognized as having an impact on the course and pathogenesis of several systemic disorders, including cardiovascular disease, bacterial pneumonia, diabetes mellitus, and low birth weight. The goal of this study is to assess the current state of oral infections, particularly periodontitis, as a cause of systemic disorders. Three mechanisms or pathways have been proposed to link oral infections to secondary systemic effects: the metastatic infection spread from the oral cavity as a result of transient bacteremia, (ii) metastatic injury from circulating oral microbial toxins, and (iii) metastatic inflammation caused by immunological injury induced by oral microorganisms. Periodontitis is a severe oral illness that can affect a person's vulnerability to systemic disease in three ways: shared risk factors, subgingival biofilms functioning as gram-negative bacteria reservoirs, and the periodontium acting as an inflammatory mediator reservoir. The above odontogenic systemic disorders have proposed evidence and mechanisms.
