Olfactory Esthesioneuroblastoma: Study of 6 Cases and Review | 86873

Medical Reports & Case Studies

ISSN - 2572-5130


Olfactory Esthesioneuroblastoma: Study of 6 Cases and Review of the Literature

Bouziane Amina*, Aassouani Farid, Kaoutar Soussy, Ait Erraisse Mohammed, Yessoufou Mahomed, Hassani Wissal, Farhan Fatima Zahra, Alami Zenab, Mustapha Maaroufi and Bouhafa Touria

Introduction: Esthesioneuroblastoma is a rare malignant tumor, which develops from olfactory neuroepithelium and is one of the rarest tumors of the nasal cavity. Its diagnosis is based on imaging and confirmed by anatom opathology.

Objective: The objective of this study is to analyze through a review of the literature, histoclinical characteristics, therapeutic means and prognostic factors of this tumor.

Study: A retrospective study concerning 6 cases of olfactory neuroblastoma treated at the department of radiotherapy of the University hospital Center in Fez, Morocco, from January 2012 to December 2017.

Results: The average age of our patients was 40 years. Clinical symptomatology was dominated by nasal obstruction and epistaxis. 5 patients were classified as Kadish C and one patient as Kadish D. 4 patients underwent surgical treatment. Concering adjuvant radiotherapy, 2 received a dose of 70 Gy (2 using the three-dimensional conformal radiotherapy technique: 3D), 1 patient received a dose of 66 Gy in 3D, and 1 patient received 66 Gy using conformal radiotherapy with intensity modulation: IMRT. 1 patient had an important loco regional extension and was above any curative treatment, two patients were in complete remission, one patient had progressive continuation, one patient had local recurrence, and the patient who received no treatment was referred to the family.

Conclusion: Olfactory esthesioneuroblastoma is a rare Sino nasal malignant tumor, characterized by clinical polymorphism and local invasion. In spite of the surgery and the radiotherapy, the forecast remains reserved on the long term.