Vladislav S.BARANOV
identification of many thousands of genes responsible
for genetic disorders expanded a lot of our knowledge
in monogenic, olygogenic & multifactor diseases thus
launching the era of “predictive medicine (PM) also to
3 PM ( predictive, preventive , personified ) ( Baranov
et al 2000, Baranov,Baranova, 2018) and somewhat later
in 2008 after inclusion of “participatory ’by ptof. L.
Hood–into 4PM . Further progressive development of
4PM was in line with spectacular achievements in molecular
genome studies . Sophisticated identification of
“predisposition” genes by means of whole genome testing
( GWAS , NGS) o f huge healthy and affected patient
cohorts enriched with system genetic approach and relevant
omics technologies significantly increased the practical
value of PM thus gradually converting it into translation
medicine(2010) which later ( 2015) gave a birth
to “precision, individual molecular medicine” . Since the
origin of PM its “sine qua non “ (dry extract) has been
represented by so called Personal Genetic Pass (GP)-the
individual DNA data bank incorporating personal
genetic information amenable for direct practical application
in clinic . The major steps, problems and advances
of PM in prediction ,prevention, individual treatment
and prognostic genetic testing as well as their contribution
in evolution of GP to its modern electronic
counterpart are briefly discussed.
