Comparison of Gabapentin Monotherapy vs. Combination Therapy | 55830

Journal of Biology and Today's World

ISSN - 2322-3308


Comparison of Gabapentin Monotherapy vs. Combination Therapy of Methyl Cobalamin and Gabapentin in Treating Diabetic Neuropathic Pain

Aisha Hasan*, Muhammad Haroon Khilan, Aizaz Khan, Mohammad Haroon Hassan, Anab Rehan Taseer, Sajid Iqbal, Mahnoor Amir and Muhammad Ashraf Chaudhary

Introduction: To evaluate effectiveness of gabapentin alone and combination therapy of gabapentin with methyl cobalamin with regards to decrease in pain in patients suffering from diabetic neuropathy.

Method: Patients studied constituted either gender with age ranging above 18 year up to 80 years. Patients suffering from diabetic neuropathy were followed in this study. They had painful neuropathic condition and were following treatment for controlling diabetes mellitus. They were divided into two groups (1 and 2) according to the type of drug used for the purpose of neuropathic pain. Group 1 patients received Gabapentin monotherapy while Group 2 patients received combined therapy of gabapentin and Methylcobalamin. Variables such as age, gender, weight, BMI, type of drug used and pain score were noted in proformas and data was then analysed with SPSS (VERSION 16).

Results: There were two groups of patients. One hundred fifty patients were receiving gabapentin (group 1). While other 150 subjects were put on the combination regimen of Gabapentin and Methyl cobalamine (group 2). On comparison of scores for pain between the two groups there was significant difference of pain decrease in the combination therapy group 2 as compared to the solo drug usage (gabapentin) in group 1. No adverse side effects of much significance were noted.

Conclusion: It is inferred from this study that combined therapy with Gabapentin and Methylcobalamin can be more efficacious as compared to treatment with gabapentin alone. This combination is safe with minimal side effects.