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Assessing the effects of dietary L-Methionine supplementation induced epigenetic alterations in type 2 diabetic rats | Abstract

Journal of Cellular and Molecular Biology Research

Abstract

Assessing the effects of dietary L-Methionine supplementation induced epigenetic alterations in type 2 diabetic rats

Umashanker Navik

Balanced nutrition plays an important role in the maintenance of healthy life. Imbalance in any of it, results in various metabolic disorders. L-Methionine (L-Met) is one of the essential amino acids which play an important role in variety of cellular processes. Reports suggest that dietary methionine restriction as well as its supplementation both have beneficial effects in animal models. But in long run methionine restriction has prominent adverse effects on bone, immune system and can cause cardiac adverse event (via hyperhomocysteinemia). Here, we report the protective effect of L-Met (0.45% L-Met supplementation in diet) on T2DM induced hyperglycemia, dyslipidemia and other complications. Interestingly, L-Met supplementation also activates hepatic p-AMPK and its downstream signaling molecule SIRT1, mimicking anti-diabetic drug metformin, an AMPK activator. Real Time PCR, results show that L-Met supplementation prevents diabetes induced increase in expression of master regulator FOXO1, hepatic DNMT1 expression and global histone H3K36 di-methylation.

 
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