Journal of Multiple Sclerosis

An Issue on Concepts and Techniques for Cytoskeletal Proteins in Health and Neurodegenerative Disease

Isabel Rust* and M. Barisic

The field has advanced quickly since we put together a well-received special issue on "Cytoskeletal Proteins in Health and Neurodegenerative Disease" for Brain Research Bulletin in 2016. This is largely because new techniques, like super-resolution microscopy, have developed and matured. Since we were asked to make a sequel, we chose to stick with the main idea while emphasising new ideas and techniques. As before, we gathered nine papers on the function of the neuronal cytoskeleton in normal and abnormal circumstances. Throughout a neuron's lengthy existence, cytoskeletal components form and are maintained. Seven of the contributions present contemporary ideas and examine these topics, as well as how they may affect physiology and neurodegenerative illnesses. Two papers concentrate on unique methodological advancements and how these methods can be applied to examine the neuronal cytoskeleton's structure and function in novel ways. The collection of articles shows that in order to adequately explore the causes and consequences of the role of cytoskeletal proteins in health and disease, future approaches must take into account the functional relationships between the individual filament systems as well as the influence that various signal transduction mechanisms have on the cytoskeleton and vice versa. In order to test important field hypotheses, we believe that this compilation will aid in the design of appropriate studies using innovative techniques