Alzheimer's Model Develops Early ADHD Syndrome | 46405

Journal of Neurology & Neurophysiology

ISSN - 2155-9562


Alzheimer's Model Develops Early ADHD Syndrome

Qiang Zhang, Guiping Du, V John, Pankaj Kapahi and Dale E. Bredesen

We describe the first invertebrate model of attention deficit hyperactivity disorder (ADHD) that reproduces its major features, including hyperactivity, male predominance, marked exacerbation by simple carbohydrates, reversible response to dextroamphetamine, and a “paradoxical response” to stimulants. This model may offer new insight into ADHD pathogenesis and treatment. Furthermore, these findings are of particular interest in light of the recent epidemiological evidence showing that patients with dementia have a high frequency of antecedent ADHD symptoms.