Acute Iatrogenic Rhabdomyolisis and Guillan-Barre' Syndrome: | 45708

Journal of Neurology & Neurophysiology

ISSN - 2155-9562


Acute Iatrogenic Rhabdomyolisis and Guillan-Barre' Syndrome: A Dangerous Association

Lucia Briscese, Elisa Giorli, Tommaso Bocci, Silvia Tognazzi, Marta Seghieri, Marco Taddei and Ferdinando Sartucci

Guillan-Barre Syndrome (GBS) is an acute, symmetrical polyneuropathy with a clinical manifestation of flaccid paralysis with areflexia and variable sensory disturbance. GBS has an incidence of 1-2 cases/100.000 inhabitants for year. The pathological spectrum of GBS includes Acute Inflammatory Demyelinating Polyneuropathy (AIDP), Acute Motor Axonal Neuropathy (AMAN) and Acute Motor Sensory Axonal Neuropathy (AMSAN). We report a case of an 81-year-old man with GBS (subtype AMSAN), secondary to a previous Micoplasma Pneumoniae infection, who presented with an elevation of Creatin Kinase (CK) serum levels, and worsened by a co-administration of statins and clarithromycin. By our knowledge there are few cases in the literature in which the association of these drugs contributed to worsening GBS.