In recent years, new Coronaviruses (CoV) have developed on a regular basis all across the world. CoVs are constantly proliferating, posing a threat to world health and the economy. Because there is no specific treatment for these CoVs, any effective method (including nutritional and dietary approaches) is worth looking into. A unique combination of vitamin C, curcumin, and glycyrrhizic acid (VCG Plus) was developed based on current breakthroughs in nutrients and phytonutrients research that offers potential against CoV infection. System biology methods were used to investigate the potential of VCG Plus in altering immune and inflammatory response targets and pathways. Along with network analysis, gene target acquisition, gene ontology, and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway enrichment were all done at the same time.
The findings demonstrate that VCG Plus has the ability to operate on 88 hub targets that are linked to immunological and inflammatory responses. VCG Plus has the ability to regulate the innate immune response by reducing PI3K/AKT, NF-B, and MAPK signaling pathways, as well as stimulate interferon production, activate and balance T-cells, and regulate the inflammatory response by inhibiting NOD-like and Toll-like signaling pathways. In studies of CoV infections, all of these biological mechanisms and pathways have been well described. As a result of our findings, VCG Plus may be useful in controlling immune responses to treat CoV infections and inhibiting excessive inflammatory responses to prevent cytokine storm. However, more in vitro and in vivo research is needed to confirm the current findings in system biology.