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A cleavable chimeric peptide-R7: enhancing the dual-function | 80266

International Journal of Innovative Research in Science, Engineering and Technology

Abstract

A cleavable chimeric peptide-R7: enhancing the dual-function of LPS neutralization and antibacterial properties against MDR E. coli

Xiumin Wang

During the last ten years, the design of new enzyme-free
electrochemical sensors based metal oxide nanoparticles has
been described. Due to the electrocatalytic activity of these
nanomaterials, these sensors allow the sensitive detection of
different ions and molecules. They can replace advantageously
enzymes due to their higher stability.
The presentation will be focused on the use of Kegging type
polyoxometallates (POMs) for the detection of nitrite ions1 and
of hydrogen peroxide. The association of POMs with single-wall
carbon nanotubes (image) allowed the increase of the sensitivity of
detection of hydrogen peroxide by a factor of 38.52. The involved
charge transfer mechanism will be detailed.
Other types of metal oxide nanomaterials such as perovskites will
also be presented. A2BO4+δ type perovskite are alternance of
perovskite ABO3 and of rock salt AO layers, A being a lanthanide and
B a metal. Detection limit of glucose is 0.5 μM and no interference
of detection is observed in human serum. The involved charge
transfer mechanism will be detailed.
This presentation shows the potentiality of metal oxide
nanomaterials for biosensing.

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